Caryotype moléculaire
arrays CGH (hybridation génomique comparative)
• Génome Humain Complet
• La Sensibilité disponible Maximale: 1 million d’oligonucléotides
• Pas besoin de culture cellulaire
• Analyse Multiple Automatisable
• Résultats en 48-72 h eures
APPLICATIONSStérilité
Pertes gestationnelles récurrentes
Analyse du tissu fœtal
Diagnostic Prénatal: AMNIOCHIP
Cardiopathies congénitales
Autres malformations congénitales
Retard mental idiopathique
Autisme
Oncologie
Références:
• Edelmann L, Hirschhorn K. Clinical utility of array CGH for the detection of chromosomal imbalances associated with mental retardation and multiple congenital anomalies. Ann N Y Acad Sci. 2009 Jan;1151:157-66.
• Slavotinek AM. Novel microdeletion syndromes detected by chromosome microarrays. Hum Genet. 2008 Aug;124(1):1-17.
• Liang JS, Shimojima K, Yamamoto T. Application of array-based comparative genome hybridization in children with developmental delay or mental retardation. Pediatr Neonatol. 2008 Dec;49(6):213-7.
• Stankiewicz P, Beaudet AL. Use of array CGH in the evaluation of dysmorphology, malformations, developmental delay, and idiopathic mental retardation. Curr Opin Genet Dev. 2007 Jun;17(3):182-92.
• Ropers HH. Genetics of intellectual disability. Curr Opin Genet Dev. 2008 18(3):241-50.
• Shaffer LG, Bejjani BA. Medical applications of array CGH and the transformation of clinical cytogenetics. Cytogenet Genome Res. 2006;115(3-4):303-9.
